Advances of Scientific Research on Technology Enhanced Learning in Social Networks and Mobile Contexts: Towards High Effective Educational Platforms for Next Generation Education

This editorial presents the latest advances of scientific Research on Technology enhanced learning in social networks and mobile contexts. It summarizes the key finding and promotes three main pillars for future scientific contribution to the domain namely: Enabling Technologies, Educational Strategies, and Next Generation Social Networks for Educational Purposes. It can serve as a position document for scientific debate fostering international collaboration and empirical research in the various aspects of the well-defined agenda. It can also serve as a reference edition for researchers interested in the adoption of Social Networks, in the Education Sector

Chinese Virtual World Adoption: Attitudes, Experiences and Issues

Abstract Virtual Worlds are receiving increased global attention in a wide range of applications in education

Introduction to game system design and the digital economy minitrack

International audienceThe purpose of the minitrack is to provide a forum for researchers to discuss the business of video game either as a market itself or as a tool for business and society. The study of the design, use and impact of these games and game like systems in various contexts can lead to important research. Topics discussed in this minitrack include: game adoption, the use of games in organizations, and the changing business of video games

Introduction to game system design and the digital economy minitrack

International audienceThe purpose of the minitrack is to provide a forum for researchers to discuss the business of video game either as a market itself or as a tool for business and society. The study of the design, use and impact of these games and game like systems in various contexts can lead to important research. Topics discussed in this minitrack include: game adoption, the use of games in organizations, and the changing business of video games

Advances of scientific research on technology enhanced learning in social networks and mobile contexts : towards high effective educational platforms for next generation education

This editorial presents the latest advances of scientific Research on Technology enhanced learning in social networks and mobile contexts. It summarizes the key finding and promotes three main pillars for future scientific contribution to the domain namely: Enabling Technologies, Educational Strategies, and Next Generation Social Networks for Educational Purposes. It can serve as a position document for scientific debate fostering international collaboration and empirical research in the various aspects of the well-defined agenda. It can also serve as a reference edition for researchers interested in the adoption of Social Networks, in the Education Sector

Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on NIR-II AIEgens

A single-component multi-modal theranostic platform taking advantage of multiple imaging and therapy techniques may offer improved diagnostic monitoring capabilities and therapeutic efficacies. In this study, through structural tuning, a novel theranostic agent TSSAM with aggregation-induced emission (AIE) characteristics, bright second near-infrared (NIR-II) emission, high reactive oxygen species (ROS) generation capability and excellent photothermal conversion efficiency (40.1%) was developed. TSSAM makes the best use of its excited state energy and keeps perfect equilibrium between radiative and non-radiative transition to satisfy the needs of both NIR-II fluorescence imaging (FLI)/photoacoustic imaging (PAI)/photothermal imaging (PTI) trimodal imaging and photodynamic therapy (PDT)/photothermal therapy (PTT) synergistic therapy. Further experiments validated the superior imaging quality and tumoricidal activity of TSSAM, in which tumor tissues were completely eradicated and tumor metastasis was effectively inhibited by merely single injection and one-time laser irradiation. This research has therefore presented a smart multifunctional material holding great promise in both basic research and clinical practice

Aggregation-Induced Emission Luminogen with Near-Infrared-II Excitation and Near-Infrared‑I Emission for Ultradeep Intravital Two-Photon Microscopy

Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is the shallow penetration depth. Two-photon fluorescence microscopic imaging with excitation in the longer-wavelength near-infrared (NIR) region (>1100 nm) and emission in the NIR-I region (650–950 nm) is a good choice to realize deep-tissue and high-resolution imaging. Here, we report ultradeep two-photon fluorescence bioimaging with 1300 nm NIR-II excitation and NIR-I emission (peak ∼810 nm) based on a NIR aggregation-induced emission luminogen (AIEgen). The crab-shaped AIEgen possesses a planar core structure and several twisting phenyl/naphthyl rotators, affording both high fluorescence quantum yield and efficient two-photon activity. The organic AIE dots show high stability, good biocompatibility, and a large two-photon absorption cross section of 1.22 × 10³ GM. Under 1300 nm NIR-II excitation, <i>in vivo</i> two-photon fluorescence microscopic imaging helps to reconstruct the 3D vasculature with a high spatial resolution of sub-3.5 μm beyond the white matter (>840 μm) and even to the hippocampus (>960 μm) and visualize small vessels of ∼5 μm as deep as 1065 μm in mouse brain, which is among the largest penetration depths and best spatial resolution of <i>in vivo</i> two-photon imaging. Rational comparison with the AIE dots manifests that two-photon imaging outperforms the one-photon mode for high-resolution deep imaging. This work will inspire more sight and insight into the development of efficient NIR fluorophores for deep-tissue biomedical imaging

Aggregation-Induced Emission Luminogen with Near-Infrared-II Excitation and Near-Infrared‑I Emission for Ultradeep Intravital Two-Photon Microscopy

Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is the shallow penetration depth. Two-photon fluorescence microscopic imaging with excitation in the longer-wavelength near-infrared (NIR) region (>1100 nm) and emission in the NIR-I region (650–950 nm) is a good choice to realize deep-tissue and high-resolution imaging. Here, we report ultradeep two-photon fluorescence bioimaging with 1300 nm NIR-II excitation and NIR-I emission (peak ∼810 nm) based on a NIR aggregation-induced emission luminogen (AIEgen). The crab-shaped AIEgen possesses a planar core structure and several twisting phenyl/naphthyl rotators, affording both high fluorescence quantum yield and efficient two-photon activity. The organic AIE dots show high stability, good biocompatibility, and a large two-photon absorption cross section of 1.22 × 10³ GM. Under 1300 nm NIR-II excitation, <i>in vivo</i> two-photon fluorescence microscopic imaging helps to reconstruct the 3D vasculature with a high spatial resolution of sub-3.5 μm beyond the white matter (>840 μm) and even to the hippocampus (>960 μm) and visualize small vessels of ∼5 μm as deep as 1065 μm in mouse brain, which is among the largest penetration depths and best spatial resolution of <i>in vivo</i> two-photon imaging. Rational comparison with the AIE dots manifests that two-photon imaging outperforms the one-photon mode for high-resolution deep imaging. This work will inspire more sight and insight into the development of efficient NIR fluorophores for deep-tissue biomedical imaging

Aggregation-Induced Emission Luminogen with Near-Infrared-II Excitation and Near-Infrared‑I Emission for Ultradeep Intravital Two-Photon Microscopy

Currently, a serious problem obstructing the large-scale clinical applications of fluorescence technique is the shallow penetration depth. Two-photon fluorescence microscopic imaging with excitation in the longer-wavelength near-infrared (NIR) region (>1100 nm) and emission in the NIR-I region (650–950 nm) is a good choice to realize deep-tissue and high-resolution imaging. Here, we report ultradeep two-photon fluorescence bioimaging with 1300 nm NIR-II excitation and NIR-I emission (peak ∼810 nm) based on a NIR aggregation-induced emission luminogen (AIEgen). The crab-shaped AIEgen possesses a planar core structure and several twisting phenyl/naphthyl rotators, affording both high fluorescence quantum yield and efficient two-photon activity. The organic AIE dots show high stability, good biocompatibility, and a large two-photon absorption cross section of 1.22 × 10³ GM. Under 1300 nm NIR-II excitation, <i>in vivo</i> two-photon fluorescence microscopic imaging helps to reconstruct the 3D vasculature with a high spatial resolution of sub-3.5 μm beyond the white matter (>840 μm) and even to the hippocampus (>960 μm) and visualize small vessels of ∼5 μm as deep as 1065 μm in mouse brain, which is among the largest penetration depths and best spatial resolution of <i>in vivo</i> two-photon imaging. Rational comparison with the AIE dots manifests that two-photon imaging outperforms the one-photon mode for high-resolution deep imaging. This work will inspire more sight and insight into the development of efficient NIR fluorophores for deep-tissue biomedical imaging